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新英格兰：Our data are also consistent with poorer neutralization of the virus with the full set of B.1.351-spike mutations than virus with either subset of mutations and suggested that virus with mutant residues in the receptor-binding site (K417N, E484K, and N501Y) is more poorly neutralized than virus with Δ242-244, which is located in the N-terminal domain of the spike protein.Data for decision making are rarely available when needed, but the “retrospect-o-scope” is always ready to judge decisions that have been made.Although the immune response to the first dose is unlikely to degrade quickly, it is incomplete, and there are no data to inform how long a second dose could be delayed without compromising effectiveness.Minimal data are available from adequately powered randomized, controlled trials.Robust safety data, including pediatric-focused studies and postlicensure monitoring for potential rare outcomes such as vaccineassociated MIS-C, are a bare minimum, as is ensuring just and equitable access to vaccination.
柳叶刀：Although race and ethnicity data on COVID-19 outcomes are limited, Black, non-Hispanic people accounted for 15·3% of the 250 572 deaths for which race and ethnicity data were available (76% of 326 015 deaths) on Feb 7, 202113—a death rate that is 1·5 times higher than the rate among white, non-Hispanic people.In addition, data from an additional month of follow-up are now available for inclusion in the analysis, providing greater precision in estimates because of the larger number of cases for analysis in comparison with the previous report.These dataindicate that ChAdOx1 nCoV-19, used in the authorised schedules, might have a substantial effect on transmission by reducing the number of infected individuals in the population.All data were anonymized according to good clinical practice guidelines and data protection regulations.Bearing in mind limited data, the present study also suggests that younger individuals are unlikely to develop severe disease, but more data are needed to confirm this supposition.
Nature:After accounting for selection bias — the fact that researchers have observed only a small portion of the outer Solar System — the data suggest that ETNOs are uniformly distributed across the sky.Temporal genomic data hold great potential for studying evolutionary processes such as speciation. Previously published data used in this study are available under accession numbers PRJEB24361 and PRJEB7929.Data from another study hint at this: extrusion stripes occur near DSBs in dividing yeast cells, but diminish following depletion of MRX (rather than cohesin).Moreover, our data also indicate that, upon DSB induction, the loop strength is reinforced, cohesin accumulates at loop anchors and the cohesin complex itself is modified by ATM within damaged TADs.
Science：Data were obtained from three to five organoids or culture wells (coverslips) in each WT and mutant cell line.Combined, these data suggest extensive transcriptional reprogramming of myeloid cell metabolism in the hematoma milieu that may modulate their functions during this period.As more data become available, we can move beyond estimating the combined effect of a bundle of NPIs and begin to understand the effects of individual interventions.Sufficient data on transmission have now accumulated to discern the effectiveness of individual interventions.Early data from Israel indicate vaccinated people who nevertheless became infected with SARS-CoV-2 have reduced levels of virus, which may make them less contagious.
Cell:Although we cannot formally exclude that some HIV-1 particles undergo uncoating before nuclear import or during NPC translocation, our data argue against it.Live cell fluorescence microscopy data were recorded on a SP8 X-SMD FLIM confocal microscope (Leica).Therefore, our data provide a potential mechanism of how excessive mechanotransduction in macrophages affects phagocytosis via calcium and Rac1 activation.The DMS data define the effect of each possible single amino acid change on both expression of the RBD and its capacity to bind hACE2.These data demonstrate that BDNF, FLX, and KET promote TRKB trafficking in dendritic spines, and this effect is disrupted in TRKB.Y433F mutants.
“The data is certainly intriguing and suggestive that vaccination may reduce the infectiousness of COVID-19 cases, even if it does not prevent infection altogether,” says Virginia Pitzer, an infectious-diseases modeller at Yale School of Public Health in New Haven, Connecticut.
《华盛顿邮报》：“The FBI reports help us identify trends, but their data is so woefully inadequate that it can’t be relied on for much,” said civil rights lawyer Arjun Singh Sethi, author of “American Hate: Survivors Speak Out.”
《纽约时报》：New data suggests premiums need to increase sharply for some homes.
《China Daily》:The Centers for Disease Control and Prevention (CDC) has recorded nearly 409,000 coronavirus cases and 1,438 deaths among healthcare personnel nationwide, but the agency acknowledges its data is incomplete.